Both Wegovy and Mounjaro are clinically proven weight-loss injections available on private prescription in Ireland. Our consultant specialist explains the differences.
GLP-1 Weight Loss Treatment
Wegovy (semaglutide) and Mounjaro (tirzepatide) are both injectable GLP-1 receptor agonists approved for chronic weight management and available on private prescription in Ireland.
| Feature | Wegovy (Semaglutide) | Mounjaro (Tirzepatide) |
|---|---|---|
| Mechanism | GLP-1 receptor agonist | GLP-1 + GIP dual receptor agonist |
| Average weight loss | ~15% body weight (STEP trials) | ~20-22% body weight (SURMOUNT trials) |
| Injection frequency | Once weekly | Once weekly |
| Cardiovascular benefit | Proven (SELECT trial) - 20% CVD risk reduction | Promising - SURPASS-CVOT awaited |
| Side effects | Nausea, vomiting, diarrhoea, constipation | Nausea, diarrhoea, vomiting, constipation |
| Starting dose | 0.25mg/week, escalate to 2.4mg/week | 2.5mg/week, escalate to 15mg/week |
Wegovy (Semaglutide)
The SELECT cardiovascular outcome trial (2023, NEJM) showed a 20% reduction in major cardiovascular events in people with obesity who had pre-existing heart disease. Wegovy is the first anti-obesity drug proven to reduce heart attacks and strokes.
Mounjaro (Tirzepatide)
Tirzepatide (Mounjaro) acts on two hormone receptors - GLP-1 and GIP. The SURMOUNT-1 trial showed average weight loss of 20.9% at the highest dose. Excellent for patients with type 2 diabetes or insulin resistance.
FAQ
Yes. At Naas Cardiology & Endocrinology Clinic, Dr Kazmi accepts self-referrals. A full medical history review including blood tests is required before prescribing.
Most patients notice appetite reduction within 1-2 weeks. Meaningful weight loss (5-10%) typically occurs within 3 months. Maximum effect at 12-16 months on maintenance dose.
Yes. Some patients switch from Wegovy to Mounjaro if they plateau, or vice versa. This transition is managed by your consultant with an appropriate washout period if required.
Start Your Treatment
Dr Kazmi, Consultant Endocrinologist (IMC 213626). Sunday appointments in Naas, Co. Kildare.