For GPs & Endocrinology Colleagues · Clinical Review

Advances in Diabetes Technology: A Clinical Review

Automated insulin delivery, CGM performance data, the growing Type 2 diabetes evidence base, and current HSE referral and funding pathways — summarised for referring GPs and endocrinology colleagues.

Dr Syed Kazmi, Consultant Endocrinologist & Diabetologist (IMC 213626) Last reviewed: September 2026 ~11 min read

Clinical Summary

Automated insulin delivery (AID) is now standard of care for Type 1 diabetes and has an accelerating evidence base in insulin-treated Type 2 diabetes. Current-generation CGM accuracy (MARD ~8%) supports insulin dosing decisions in most circumstances. This review, authored by Dr Syed Kazmi, Consultant Endocrinologist and Diabetologist at Naas Cardiology & Endocrinology Clinic (IMC 213626), summarises the current device landscape, key 2025–2026 trial data, and the practical referral/funding pathway for patients in Ireland.

AID Systems & Real-World Outcomes

Three hybrid closed-loop systems dominate current UK/Ireland and European practice: Medtronic MiniMed 780G, Tandem t:slim X2 (Control-IQ+), and Insulet Omnipod 5. All use predictive/model-based algorithms to auto-adjust basal insulin and deliver automatic correction boluses; none yet fully automate meal-time dosing.

Real-world glycaemic outcomes, n=213, Khan et al., Diabetic Medicine 2026
SystemCGM pairingTime-in-range changeNotes
Medtronic MiniMed 780GGuardian sensors+21.1%780G is a closed ecosystem; the newer sibling MiniMed Flex (FDA-cleared March 2026, screenless, half the size) breaks this pattern — pairs with Simplera Sync and Abbott's Instinct sensor, and is also cleared for insulin-requiring Type 2 diabetes
Insulet Omnipod 5Dexcom G6/G7, Libre 2 Plus, Libre 3 Plus (added 2025–2026)+15.2%Tubeless; broadest paediatric use; first system cleared for Type 2 diabetes (August 2024)
Tandem t:slim X2 (Control-IQ+)Dexcom G6/G7; Libre 3 Plus (from July 2026)+10.1%Touchscreen; sleep/exercise activity modes. Libre 3 Plus support live in UK, Switzerland, Sweden, Finland, Italy — not yet confirmed for Ireland at time of writing
Interpretation caveat: the Khan et al. (2026) real-world study used different CGM systems across cohorts, so these time-in-range figures should not be read as head-to-head superiority evidence — all three systems produced clinically meaningful improvement. Khan et al., 2026 — PubMed.

CGM Accuracy & Integration

Current-generation CGM specifications relevant to clinical prescribing
ParameterDexcom G7FreeStyle Libre 3 / 3 Plus
Adult MARD~8.2% arm-placed (pivotal trial)~7.9% (Libre 3 pivotal trial; no separate Plus-specific figure identified)
Warm-up30 min60 min
Sample rateEvery 5 min (288/day)Every 1 min (1,440/day)
AID integrationBroadest — Tandem Control-IQ+, Omnipod 5Expanding — Omnipod 5 (2025–26); Tandem t:slim X2 from Jul 2026 (UK/EU markets; not yet confirmed for Ireland)
HSE LTI listList B (Dexcom G6/G7)List A (Libre 2); Libre 3 Plus not yet on List A

Both sensors remain within accuracy bands considered suitable for insulin dosing without routine confirmatory fingerstick testing, consistent with manufacturer labelling. Device choice for a given patient is more often determined by pump compatibility and HSE reimbursement list status than by the marginal MARD difference. Manufacturer comparison data.

Type 2 Diabetes: The AID Evidence Base

Until recently, AID was used almost exclusively in Type 1 diabetes. That has changed rapidly over 2025–2026:

Clinical implication: insulin-treated Type 2 diabetes patients with recurrent hypoglycaemia, high glycaemic variability, or HbA1c persistently above target on optimised MDI now represent a reasonable population for specialist AID assessment, pending local funding availability. Note the TIR benefit in the 2026 meta-analysis is graded low-certainty evidence — reasonable to discuss with patients as an emerging rather than fully established benefit. Systematic review and meta-analysis — PMC.

Connected Insulin Pens

For patients on multiple daily injections who are not pump candidates or do not wish to use one, connected pens (NovoPen 6/Echo Plus, InPen) provide automated dose-timing data and bolus calculation, improving adherence visibility at review. A Swedish real-world study found NovoPen 6 use associated with up to two additional hours per day in target glycaemic range compared with standard pens — useful data to discuss when a patient is ambivalent about pump therapy but has adherence or dose-timing concerns. Diabetes Ireland.

Non-Invasive Monitoring — Current Status

Patients increasingly ask about smartwatch/smart-ring "glucose monitoring." Clinicians should be aware the FDA issued an explicit safety communication on 21 February 2024 stating no such device is approved, cleared, or authorised for glucose measurement, and that inaccurate readings can lead to incorrect insulin or sulfonylurea dosing with potentially severe consequences (confusion, coma, death). This is a useful point to proactively raise, particularly with patients considering discontinuing an approved CGM in favour of a wearable claim. Genuine non-invasive sensing (Biolinq Shine — FDA De Novo classification 23 September 2025 — uses a shallow intradermal microsensor array, not a needle/filament) remains positioned for non-insulin-dependent Type 2 diabetes use at present, not as an insulin-dosing-grade replacement for CGM. FDA Safety Communication.

Referral Criteria & HSE Funding Pathway

Consider specialist referral when:

Current HSE funding pathway

  1. CGM (LTI scheme): Reimbursed since December 2023 for Type 1 diabetes patients insulin-dependent from onset. List A (Dexcom One+, FreeStyle Libre 2) is default; List B (Dexcom G6/G7, Medtronic Guardian, GlucoRx Aidex) requires documented clinical justification, most commonly pump incompatibility.
  2. Insulin pumps: Free via HSE community-funded schemes; consumables via LTI. Most adult centres require structured education (DAFNE) pre-initiation — refer early given waiting-list length in several centres.
  3. Type 2 diabetes CGM: Not yet routinely funded. As of October 2025, HSE Medicines Management Programme and National Clinical Programme for Diabetes have jointly requested HIQA include a CGM HTA for insulin-dependent Type 2 diabetes in the 2026 workplan — outcome pending.
  4. Diagnostic technicality gap: Diabetes Ireland reports 500–700 patients with delayed/complex Type 1 diagnoses are currently excluded from LTI CGM funding on a documentation technicality; flag such cases for specialist input if reimbursement is unexpectedly refused.

GP referrals can be sent via Healthmail or the standard referral pathway — see referral information for details.

Frequently Asked Questions

Type 1 diabetes patients who have required insulin from disease onset are eligible. List A (Dexcom One+, FreeStyle Libre 2) applies by default; List B (Dexcom G6/G7, Medtronic Guardian, GlucoRx Aidex) requires documented clinical justification such as pump incompatibility. Patients with delayed or atypical Type 1 diagnoses may currently be excluded on a documentation technicality — this is under active review. Type 2 diabetes CGM funding is under HIQA HTA review as of 2026, not yet routine.
A 2025 NEJM RCT and a 2026 meta-analysis of nine RCTs (714 adults) found an 18.43% time-in-range improvement (low-certainty evidence) and a 1.02 percentage-point HbA1c reduction (moderate-certainty evidence), with no increase in hypoglycaemia. Real-world data from 26,427 MiniMed 780G Type 2 diabetes users corroborates trial findings. Omnipod 5 has held Type 2-specific FDA clearance since August 2024, and MiniMed Flex since March 2026, with further systems in active trials.
Consider referral for HbA1c persistently above target despite optimised MDI, recurrent/severe hypoglycaemia, hypoglycaemia unawareness, significant glycaemic variability, pregnancy planning, or patient preference after counselling. Most centres require DAFNE-equivalent structured education first — early referral helps given typical waiting-list length. Insulin-treated Type 2 diabetes with similar instability is increasingly appropriate for assessment given emerging evidence.
Dexcom G7 (~8.2% MARD) and FreeStyle Libre 3 (~7.9% MARD) are both within clinically actionable accuracy for insulin dosing without routine confirmatory fingerstick testing, per manufacturer labelling. Device selection is usually better guided by pump compatibility and HSE reimbursement list status than by this marginal accuracy difference. Advise patients to confirm with fingerstick when symptoms are discordant with sensor readings.

References

  1. Khan et al. Real-world glycaemic outcomes with Medtronic 780G, Tandem Control-IQ and Omnipod 5 automated insulin delivery systems. Diabetic Medicine, 2026. Wiley / PubMed
  2. A Randomized Trial of Automated Insulin Delivery in Type 2 Diabetes. New England Journal of Medicine, 2025. NEJM
  3. Efficacy and Safety of Automated Insulin Delivery in People With Type 2 Diabetes: A Systematic Review and Meta-Analysis. PMC, 2026. PMC / PubMed
  4. Performance of an Automated Insulin Delivery System in People Living With Type 2 Diabetes and Insulin Resistance: First Real-World Evidence in 26,427 Users. PubMed, 2025. PubMed
  5. Automated Insulin Delivery in Adults With Type 2 Diabetes: A Nonrandomized Clinical Trial. PMC. PMC
  6. Innovative Automated Insulin Delivery System for Type 2 Diabetes (twiist-T2D). ClinicalTrials.gov. ClinicalTrials.gov
  7. FDA Safety Communication: Do Not Use Smartwatches or Smart Rings to Measure Blood Glucose Levels. FDA.gov
  8. HSE GP Circular 029-23 — Continuous Glucose Monitoring (CGM). HSE.ie
  9. HSE seeks assessment of glucose monitoring reimbursement for insulin-dependent type 2 diabetes. Irish Medical Times, 2026. IMT.ie
  10. Diabetes Ireland — Budget 2026 diabetes technology funding advocacy. Diabetes.ie
  11. Diabetes Ireland — Novo Nordisk smart insulin pen launch in Ireland. Diabetes.ie
  12. Insulet Corporation — Omnipod 5 Automated Insulin Delivery System is now FDA-cleared for People with Type 2 Diabetes (SECURE-T2D trial data). Insulet investor news, Aug 2024
  13. MiniMed — FDA Clearance of MiniMed Flex, screenless smartphone-controlled insulin pump. MiniMed newsroom, Mar 2026
  14. Tandem Diabetes Care Launches t:slim X2 Compatibility with Abbott FreeStyle Libre 3 Plus Sensor in Five International Markets. Tandem investor news, Jul 2026
  15. Biolinq Shine Granted De Novo Classification by U.S. FDA for the First Fully Autonomous, Needle-Free Glucose Sensor. Biolinq.com, Sep 2025
  16. Accuracy and Safety of Dexcom G7 Continuous Glucose Monitoring in Adults with Diabetes. PMC. PMC
  17. Abbott — Late-Breaking Data Demonstrate FreeStyle Libre 3 System is Most Accurate 14-Day CGM (ADA 2022). Abbott newsroom
  18. Irish Medical Times — HSE to reimburse glucose monitoring systems for all type 1 diabetes patients. IMT.ie, Dec 2023
This review reflects publicly available data as of September 2026 and is intended to support, not replace, individual clinical judgement and current HSE/manufacturer guidance, which may change. Verify current LTI list status and funding criteria directly with the HSE Medicines Management Programme before advising patients.

Refer a Patient for Diabetes Technology Assessment

Dr Kazmi accepts GP and specialist referrals for CGM, insulin pump, and AID assessment, including insulin-treated Type 2 diabetes. Referrals via Healthmail preferred.

Referral Information Contact the Clinic